The BioDE Lab (Biomolecular Dynamics & Engineering) at the University of Patras uses molecular simulation and theory to explain how biomolecular machines work — how they move, fold, and assemble — and applies that knowledge to engineer new molecular tools. We work at all-atom resolution, in close dialogue with experimental collaborators.
Our interdisciplinary team draws on physics, chemistry, biology, and engineering to tackle open questions at the molecular scale — from fundamental mechanisms to translational applications.
Three connected pillars, from solar energy conversion to engineered molecular tools.
The antenna complexes of plants and diatoms: how light is captured, funnelled to the reaction centre, and safely dissipated under stress.
Learn moreHow proteins tune metal centres to reduce oxygen, detoxify nitric oxide and bind small ligands — probed with DFT, QM/MM and spectroscopy.
Learn moreSimulating CRISPR-Cas and Fanzor nucleases to explain specificity, and engineering nucleases, enzymes and transporters with improved function.
Learn moreWe're always interested in hearing from motivated students and researchers who want to work at the interface of physics, biology, and engineering.
Get in TouchProbing intrinsically disordered proteins with computational tools — Athens, 23–25 October 2026.
Karvounis IG and Daskalakis V reveal a dual gating mechanism with implications for nickase engineering.
The Horizon Europe MSCA network SPROUT (2027–2031) funds doctoral training on stress and photosynthesis.